Principles Of Toxicology And Risk Assessment
Principles Of Toxicology And Risk Assessment
Question:
Safety Assessments For Stevia
Non-nutritive sweeteners (NNS) have been suggested for use in connection with improving oral health, diabetes care, general reductions in caloric intake, and as anti-hypertensive agents etc.
Over the years, many NNS (e.g. cyclamate, aspartame) have also been associated with public concern over safety. Sugar substitutes, low calorie sweeteners or NNS are defined as chemical additives that give a sweet taste to foods without contributing significant calories or promoting tooth decay. The first NNS were introduced in late nineteenth century (saccharine). Most NNS exhibit 100-200 times the sweetening action shown by sucrose.
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Order Paper NowSeven NNS are now approved for use in the US and many other jurisdictions1. Within the EU, you will find 15 NNS designated as the “900 series”, i.e. food additives with E-numbers between 950 and 967. The overall aim of this assignment is to apply the principles of toxicology to risks and safety issues related to sweeteners. For this case study we use the sweetener, stevia.
Task:
Critically evaluate the range of new evidence provided by petitioners in or after 2008 to support safety claims for the non-nutritive sweetener stevia. In your answer consider the following points:
- History of use
- Technical data and product specifications )
- Biological data related to ADME
- Toxicological data related setting ADI
- Pre 2008 objections to safety petitions
